Abstract
A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzothiazoles / chemical synthesis
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Benzothiazoles / chemistry
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Benzothiazoles / pharmacology*
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Drug Design
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Molecular Structure
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Protein Kinase Inhibitors / chemical synthesis
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
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rho-Associated Kinases / antagonists & inhibitors*
Substances
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Benzothiazoles
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Protein Kinase Inhibitors
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rho-Associated Kinases